There are also some batters who could change the course of the match with their disastrous batting in a single over. In the following listicle, we will discuss the top seven batters to score most runs in an over in ODIs. Most Runs in an Over in ODI 7. Liam Livingstone - 32 runs against Philippe Boissevain in 2022 Liam Livingstone gave a big finish to England when they posted the highest-ever ODI total of 498/4 against the Netherlands on June 17, 2022. During his knock of 66(22) runs, Livingstone smashed 32 runs in an over against Philippe Boissevain hitting two fours and four sixes.