We often see batters going for big overs in T20I cricket to lay the foundation for a big total in a match. In the following listicle, we will have a look at the top seven players to score most runs in an over in T20Is. Most Runs in an over in T20I 7. Ryan Burl - 34 runs against Nasum Ahmed in 2022 Ryan Burl smashed 34 runs in an over against Nasum Ahmed in a match between Zimbabwe and Bangladesh in Harare on August 2, 2022. During his 54-run knock, Burl smashed five sixes and a four in Ahmed's over.